Equator Therapeutics
Equator Therapeutics, based in San Francisco, CA, is a healthcare company in the therapeutics sub-industry, developing innovative drugs to enhance metabolism and treat metabolic disorders by targeting mitochondrial functions.
Company Overview
Equator Therapeutics is a healthcare company based in San Francisco, CA, USA. The company operates in the therapeutics sub-industry and is developing a drug to increase metabolism and burn calories without exercise. It aims to address the root cause of metabolic disorders by targeting mitochondria to generate heat. Equator Therapeutics is part of the Y-Combinator W20 batch and has a branch in Osaka, Japan, as well as a presence in both the United States and wider American regions.
Products and Drug Development
Equator Therapeutics is working on a drug designed to increase metabolism and burn calories without the need for exercise. This drug addresses metabolic disorders by focusing on mitochondrial function, specifically targeting mitochondria to generate heat. The company has developed a unique high-throughput drug discovery platform to identify compounds that activate these target proteins without side effects.
Research and Publications
Equator Therapeutics has published noteworthy research articles, including 'Mitochondrial uncouplers induce proton leak by activating AAC and UCP1' in Nature (2022) and 'H+ Transport is an Integral Function of the Mitochondrial ADP/ATP Carrier' in Nature (2019). These publications delve into the mechanisms of proton leak through mitochondrial uncouplers and the role of ADP/ATP carriers in H+ transportation.
Scientific Advisory Board
The Scientific Advisory Board at Equator Therapeutics includes leading experts in thermophysiology, metabolic disorders, and computational chemistry. The board's insights support Equator Therapeutics' research and drug development efforts, particularly in bioelectricity, computational chemistry, and high-throughput interrogation of mitochondrial physiology.
Expert Team Members
Equator Therapeutics' team comprises experts like Yuriy Kirichok, Ph.D., known for his discoveries in bioenergetics and fertilization. Junji Suzuki, Ph.D., developed CEPIA, a series of fluorescent indicators for studying calcium signaling in the endoplasmic reticulum and mitochondria. Liliya Khasin, Ph.D., focuses on identifying compounds that stimulate mitochondrial metabolism and has conducted significant fertility research.
